Developing Innovative Strategies
FIGHTING CANCER
This time lapse video shows PSMA CAR T cells (green) mediating cytotoxcity against LNCaP prostate cancer cells (red) over a 24 hour period.
RESEARCH PROJECTS
PROJECT 1
TDRD1 is a cancer-testis antigen overexpressed in about two-thirds of primary prostate tumors. It contains tudor domains that bind arginine-methylated proteins and plays an important role in cancer development. Our lab investigates its molecular functions in cancer progression and explores strategies to therapeutically target TDRD1 in prostate cancer.
PROJECT 2
Our lab is developing PSMA-targeted CAR T cell therapy for the treatment of solid tumors. This project aims to optimize CAR design and manufacturing to achieve potent antitumor efficacy while ensuring safety and controllability, with the ultimate goal of delivering an effective and safe cell therapy for patients.
PROJECT 3
Our lab investigates the molecular alterations driving antiandrogen resistance in prostate cancer. We study changes in chromatin architecture, spatial genome organization, and non-coding RNA expression to understand how these epigenetic factors reshape the transcriptome during resistance. The goal is to identify new therapeutic targets for advanced prostate cancer.
TEAM
Our team has both graduate students and undergraduate research interns who bring energy, curiosity, and diverse perspective to the lab. Together, we form a dynamic and motivated group driven by a shared enthusiasm for science and a dedication to advancing cancer discovery.
Qin Feng, Ph.D.
Associate Professor
Department of Biology and Biochemistry
Contact
qfeng4@central.uh.edu
(832) 842-8824
ALUMNI
Amrita Barua
Hussain Kalavadwala
Aroshi Mitra
Ahsan Omer
Jacky Wu
Zheng Zhang
Yujing Gao
Alexa Le
Steven Nguyen
Salman Promon
Vincent Yu
Tianyi Zhou
Yali Han
Taevien Loa
Tran Nguyen
Abid Raza
Sharon Zachariah
Visit Us
University of Houston
Center for Nuclear Receptors and Cell Signaling
Science & Engineering Research Center Building
3517 Cullen Blvd, Third Floor
Houston, Texas 77204-5056